|
Obesity
|
0.020 |
Biomarker
|
disease |
BEFREE |
The SOCS2 protein is an important modulator of obesity that regulates the metabolic pathways related to adipocyte size.
|
31816561 |
2020 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
The expressions of miR-196a, miR-196b and suppressor of cytokine signaling 2 (SOCS2) were measured in HCC tissues and cells by quantitative real-time polymerase chain reaction or immunohistochemistry.
|
30988277 |
2019 |
|
Lean body mass
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.
|
30593698 |
2019 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
This study demonstrated that miR-492 was over-expressed in PCa and exerted tumor-promoting function in PCa cells via repressing SOCS2 expression.
|
30779065 |
2019 |
|
Malignant neoplasm of prostate
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
MiR-492 exerts tumor-promoting function in prostate cancer through repressing SOCS2 expression.
|
30779065 |
2019 |
|
Prostate carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
MiR-492 exerts tumor-promoting function in prostate cancer through repressing SOCS2 expression.
|
30779065 |
2019 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Analysis based on TCGA database indicated that NR1H4 and SOCS2 were downregulated in liver cancer, this suggest NR1H4 and SOCS2 may play an important role in tumorigenesis.
|
30787420 |
2019 |
|
Acromegaly
|
0.030 |
Biomarker
|
disease |
BEFREE |
Suppressor of cytokine signaling (SOCS) 2, a negative regulator of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), which is associated with acromegaly and cancers, is a promising candidate molecule for treating various diseases.
|
30343638 |
2019 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
SOCS2 promoted leukemogenesis as well as the abundance, quiescence, and activity of AML stem cells.
|
31235852 |
2019 |
|
Myeloid Leukemia, Chronic
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Moreover, our analysis revealed that SOCS2 levels are significantly increased in patients with acute and chronic myeloid leukemia, two hematological malignancies where disease progression is closely linked to IL-1β.
|
31775389 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SOCS2 was confirmed as a target of miR-875, and the expression of SOCS2 was markedly decreased in NSCLC tissues.
|
31298374 |
2019 |
|
Kidney Failure, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Lastly, we confirmed decreased AhR and increased SOCS2 expression in monocytes of patients with end-stage renal disease, indicating the activation of AhR.
|
31284759 |
2019 |
|
Acute monocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness.
|
31235852 |
2019 |
|
Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These studies show KIAA0317 to be a critical mediator of pulmonary inflammation through its degradation of SOCS2 and a potential candidate target for therapeutic inhibition.
|
31578312 |
2019 |
|
Hematologic Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Moreover, our analysis revealed that SOCS2 levels are significantly increased in patients with acute and chronic myeloid leukemia, two hematological malignancies where disease progression is closely linked to IL-1β.
|
31775389 |
2019 |
|
Leukemogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
SOCS2 promoted leukemogenesis as well as the abundance, quiescence, and activity of AML stem cells.
|
31235852 |
2019 |
|
Progression of prostate cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study demonstrated that miR-492 was over-expressed in PCa and exerted tumor-promoting function in PCa cells via repressing SOCS2 expression.
|
30779065 |
2019 |
|
Chronic kidney disease stage 5
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Lastly, we confirmed decreased AhR and increased SOCS2 expression in monocytes of patients with end-stage renal disease, indicating the activation of AhR.
|
31284759 |
2019 |
|
Pneumonitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These studies show KIAA0317 to be a critical mediator of pulmonary inflammation through its degradation of SOCS2 and a potential candidate target for therapeutic inhibition.
|
31578312 |
2019 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Alterations in the p53-SOCS2 axis contribute to tumor growth in colon cancer.
|
29622769 |
2018 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Here, we show that SOCS2 were significantly downregulated in tumour foci in NSCLC patients.
|
29559623 |
2018 |
|
Neoplasm Metastasis
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, we also revealed that miR-196b/SOCS2 expression correlated with T stage and cervical metastasis. miR-196b was demonstrated to be an independent prognostic factor for overall survival of patients with LSCC.
|
29753737 |
2018 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The SOCS1 and SOCS2 expression levels had the best specificity and sensitivity values respectively for breast cancer diagnosis.
|
30453988 |
2018 |
|
Colitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
SOCS2 overexpression was detected in a murine model of azoxymethane/dextran sulfate sodium-induced colitis-associated colon cancer compared to mock-treated controls.
|
29622769 |
2018 |
|
Diabetic Nephropathy
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The IGF1R inhibitor blocked pathological changes induced by the over-expression of IGF1 in DKD without up-regulating SOCS2 protein levels.
|
30254418 |
2018 |